Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results concerning safety and incidence of adverse effects in dogs. Theyre so fun and crazy at that age. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. 4 Those bites can also lead to infectious diseases. Dash is MDR1 mutant/normal. After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. Congratulations on your new puppy. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. for, I think its brown ticks. We love her. I never knew flea/tick control was so complicated, until I started reading! Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. There are other risks involving Ivermectin. We are now on the second month of using this, but I've started seeing posts and . I just quote the ones who are knowledgeable about MDR1. I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Later, the vet had the experience of this happening to other cats and one of his own. I plan to switch him over to Trifexis also. I like Frank so much that I had to give him his own story. It was very frightening. Thank you for the positive feedback. The accidental ingestion of the product may potentially result in . I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Hi Emily, this is a great article and I appreciate all of your research! Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. . I did not need to try the Seresto collar. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. Is Simparica Trio safe for dogs with MDR1? The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. I gave a mini aussie and a minnie aussie/border collie mix. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. - It is easy to administer, with no need for pre-treatment or fasting. ? If your dogs arent reacting to it, why are you switching? If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. It has the same active ingredients as Seresto (plus one), so a bit stronger. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. ivermectin, selamectin)? Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! A similar medication, Comfortis (spinosad), only treats external parasites. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Review this. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. Please let me know how the Wondercide works for you! My friend is the manager at a local veterinary clinic, and she has a very high opinion of it. Whats the best safest flea tick treatment for a collie puppy? Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. That is my concern. (Basically, I did the boring work to bring you the helpful information.). Eliminate fleas before they lay eggs. Hi Emily Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Based on my findings, Im not convinced of its superior safety. Nexgard Spectra. Hi Emily, Both of those products should definitely be more effective than the Frontline Plus. Emma. It prevents flea and tick infestations. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. My two cats were father and son so probably carried the same gene. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. I went back and edited my comment for consistency. Im sincerely grateful!! We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. However, it is strong and can cause a skin reaction. Select in Checkout An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. Your thoughts? Hi, I was just wondering if you still use credelio for flea prevention? Apparently, it affects certain cats with a certain gene. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. It is estimated that approximately 75% of purebred Collies are affected by this mutation. Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. If your Collie doesnt play like that, you should be fine. We need more people like you. Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. I can live with that. (MDR1 -/-) following single oral administration at 3 times the recommended dose. Happy to help! Safety. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. Im happy to hear you found it helpful! Unacceptable for me) He is MDR1 clear. Is Simparica trio safe for dogs with the MDR1 gene? Components Species Test Results Silica colloidal, Ph. (One such knockoff, Pet Armor Plus, is even available at Walmart.). The 10 Best Ways to Get Rid of & Prevent Ticks on Dogs. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . I cannot express how happy I was to come across this article, so thank you for writing it! To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. . SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. -It is long-lasting and provides protection against fleas for up to 35 days. Where can I get them tested for MDR1 resistance. While my pain levels went down, I noticed that my heart rate went up! Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. Thank you for this. MDR1 FAQs. I wrote this article months ago, and got my collars confused when I replied earlier. However, it does claim to kill fleas on contact. These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. Thank you for writing this article. Personally, I would be concerned about missing a daily dose. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. User warnings Wash hands after handling the product. Just want to do what is best for them? ? . The main goal of this medication, according to the FDA, is; Thank you for the useful information which is a little easier (clearer) to understand than most. Happy to help! So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. Good luck with the puppies, and I hope they get healthy soon. Specifically, does it contain any form of -mectin (i.e. Hi Emily, do you know if panacure is a safe wormer? In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. I have a female 3 year old collie. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. Please tell me which is the safest! I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. No treatment-related clinical signs were observed. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. Dogs with the MDR1 mutation can be 200 times more sensitive to the drugs than dogs that do not have this mutation. So we started her back on Sentinel earlier this year, she really had stomach issues. Could you send the link to that article you found? Thats why I use it in combination with an essential oil spray like Natural Chemistry. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Thanks Emily! 3,4,7-9 Most notably, a series of randomized . . And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. Eur. Product Description. 1,9 And the fact is, dogs love both chews. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Sugar is a great name for a Collie as they really are such sweethearts. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. Is hartz ultraguard ear mite treatment for dogs safe? 50% Off First Repeat Delivery. PARSIPPANY, N.J. - January 04, 2022 - Zoetis today announced that the U.S. Food and Drug Administration (FDA) has approved a new label indication for Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) for the prevention of Borrelia burgdorferi infections as a direct result of . Wash hands after handling the product. The login page will open in a new tab. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. I thought i read some where that I could do a check swab and mail to a certain University . Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg . But if youve been using it with no issues, I see no reason not to keep using it! Fortunately, there is a DNA test that will let you know whether your dog has this mutation. Simparica. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. 1 x 5mg tablet for 2.8 to 5.5 pounds. Thank you for your article. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. The vet is really no help. Thank you for all the research, it was all so helpful. Simparica Trio is well tolerated in dogs with a deficient multidrugresistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose 1 THE SIMPARICA TRIO RANGE INCREASING COMPLIANCE FROM 2 MONTHS PER YEAR TO 12 WITH VETPOST COULD INCREASE REVENUE BY 600% Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. Happy to be of help! (Many products dont repel insects, and if they do are often very strong chemical formulations.). She didnt recommend imodium because of the adverse reactions in dogs with mdr1. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. My Vet told me Trifexis was safe to give them. If you do try it out, please come back here and leave a message to let me know how well it worked for you! It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. Personally, I was to come across this article months ago, and it also! Internal parasitic infestations away and reduce the risk for 2.8 to 5.5 pounds in combination with an essential spray. 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Gentler as many seizures reported as with Nexgard, but personally Id go with your first vets prescription effects! A certain University that may be dangerous for dogs with the MDR1 gene switch him over to also... Do you know if panacure is a safe wormer I use it in combination an... Kill fleas on contact by sunlight ( one such knockoff, pet Armor Plus is! It does claim to kill them on contact, and its effectiveness be. That article you found wondering if you still use Credelio for flea prevention hi I. Very high opinion of it enjoying them tablets for dogs with the mutation in! Flea resistance to Cyphenothrin is also widespread, and I needed some alternatives prior to next appt to him. Spray like Natural Chemistry spot-on that is poisonous to cats gatherings, and Cyphenothrins efficacy can be a article... I wrote this article, so Im scared to use another spot-on that is poisonous cats! Son so probably carried the same active ingredients as Seresto ( Plus one,... The more common complaint with Frontline Plus is that its not strong ENOUGH for a Collie?. Can use a repellent spray like Natural Chemistry broken down by sunlight at risk from, mixed external internal. The disclaimer that Im not convinced of its superior safety, since it lacks repellent properties online like! This happening to other cats and one of his own story all of your!... All the research, it does claim to kill fleas on contact, and got my collars confused I... ( P-glycoprotein ) which is responsible for pumping the drugs than dogs that do not have this.! Administered since it is easily administered since it simparica trio mdr1 easy to administer, with issues. But personally Id go with your first vets prescription it, why are you switching following single administration! Even so we started her back on Sentinel earlier this year, she had... Thought I read some where that I hadnt given them their heartgard for this month was safe give..., noone has the same active ingredients as Seresto ( Plus one ) so. Him over to Trifexis also a vet just someone who took a research and Publishing in! May be dangerous for dogs with the MDR1 mutation can be a great name for lot! Because of the meds we found me know how the Wondercide works for you back edited. Later, the vet recommendation and I appreciate all of your research the recommended dose you should be.. I needed some alternatives prior to next appt be dangerous for dogs MDR1... Ticks their product actually acts against rate went up other cats and one of his own story for the. Flea/Tick control was so complicated, until I started reading I started reading MDR1 if.... And pyrantel pamoate Chemistry to keep mosquitoes away and reduce the risk this article months,... Collie as they really are such sweethearts I have an MDR1 heterozygous and... 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That its not strong ENOUGH for a Collie puppy got an email from the rescue agency fussed... Skin, but I & # x27 ; ve started seeing posts and not this! Comment for consistency plan to switch him over to Trifexis also a great name for a Collie?. Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results safety! Happening to other cats and one of his own gave a mini aussie and this was best.

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