And 7% of the women had a bone fracture. There were many 55 year olds saying they walked like a 90 year old, etc. Thanks, everyone. Anyway. I had a lumpectomy and have just finished radiotherapy. Web Anastrozole may be taken with or without food. I really would like to try putting it on all over and maybe covering it and letting it sit overnight, but that would be when disaster happens and I would have to quick run out and my hair would be all greased up!!!! I don't wear the wig all the time - I may do eventually, but it does make me feel much more confident. I have many side effects, including hair thinning. I had two lumpectomies and the lymph nodes removed on one side. Go to the Breast Cancer Support Group. Connect with thousands of patients and caregivers for support and answers. It goes on the top and it's integrated into your own hair. Hormone therapy for cancer that spreads to other parts of the body (metastatic breast cancer) sometimes combines hormone therapies with targeted therapy. WebHair loss is found among people who take Prometrium, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years. At that point, I needed to reassess my situation. The phase IV clinical study analyzes which people take Prometrium and have Hair loss. I felt like I couldnt manage the skin issues without getting off the drugs. I completely understand how you feel. Using alcohol or tobacco with certain medicines may also cause interactions to occur. I shudder to think how Id be feeling if I were still taking those drugs today. I completely understand how you feel. May make these conditions worse. Registered Office: Fifth Floor, Ibex House, 4247 Minories, London EC3N 1DY. My Oncologist changed my med. My hair has been thinning since the menopause and has fallenout a bit but I'm not sure if it's caused by the operation or the drug. Anastrozole is used to treat early hormone receptor-positive breast cancer. But, I wish I could have. I took it for 7 weeks in August and September this year. @cautiousoptimism, What other side effects have you been dealing with? Hi @tinalove, welcome to Connect. It basically attaches to your hair using a light net which has real hair. I think that I will have to have a chat mith my breastcare nurse. The thing you have to weigh is the cancer. I did agree to radiation treatments and went through 28 rounds of radiation. This medicine comes with a patient information leaflet. Difficulty in moving; muscle cramps or stiffness; swollen joints; For Healthcare Professionals. Do not take other medicines unless they have been discussed with your doctor. Plymouth Meeting, Pa.: National Comprehensive Cancer Network. They do a lot of extension work. The last few months my hair is falling out. You'll meet with your cancer doctor (oncologist) regularly for follow-up visits while you're taking hormone therapy for breast cancer. It is created by eHealthMe based on reports of 5,159 people who have side effects when taking Prometrium from Copyright 2023 IBM Watson Health. The worst side effect I had was hot flashes, but I was undergoing radiation and it Wilmington, Del. It would be nice to get a first-hand experience for someone who has taken hormone therapy. No one told me how prevalent this is with Anastrozole. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Femara (prescribing information). Accessed Dec. 28, 2018. I began to experience hot flashes that were more intense than when I was going through menopause. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). The decision to walk away from taking aromatase inhibitors is a choice many women are now making. I took that drug, it made my knees and joints hurt so bad that I could not walk, I had to change drugs, I am now on Letrolzole, it has side effects too but so far nothing like the anastrozole. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements. As I said, I only dabbed it on my upper hairline by face and where my hair parts. In my particular case, I was post-menopausal when diagnosed with stage 2B invasive ductal carcinoma. Hair loss may occur if male or female hormones, known as androgens and estrogens, are out of balance. Good luck. Accessed Dec. 28, 2018. I just started Biotin with the hope it will help. The post reveals that the aforementioned can adversely cause hair thinning as well as hair loss in men and even in women. Good luck! By then damage has been done. Aromatase inhibitors are only used in women who have undergone menopause. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Mayo Clinic is a not-for-profit organization. "Product Information. Differentside effects can occur when takingAnastrozole, but there are ways of coping and I hope some of this infomation is useful. And 7% of the women had a bone fracture. My main complaint with tamoxifen was uncontrollable mood swings and joint pain. Youll notice that I moved your message into the Breast Cancer group. You might want to discuss this with yours. In late May 2022, though Im not anemic, I started taking an over the counter iron supplement (with Vitamin C) on my own, which has stopped my hair from coming out whenever I slightly pull on it or run my fingers through it. @tinalove asked this very question a little while ago, so I moved your message to this discussion thread. I put it on a cotton ball and dab it lightly on the areas by my temples and my natural hair part and my hairline by my forehead. Also HRT does wonders for your hair, so coming off that hasn't helped. Ischemic cardiovascular disease (4%) has also been reported. In 2020, I received the same diagnosis in the same breast and underwent a second lumpectomy. Ask your healthcare professional how you should dispose of any medicine you do not use. I know this was posted a year ago but I just wondered if you carried on with the meds or came off them? Journal of Clinical Oncology. I noticed a little hair thinning less than 4 months after taking it. Cerner Multum, Inc. "Australian Product Information." It is expensive but when I calculated it over a year it worked out much the same as going to my hairdresser every six weeks. The phase IV clinical study analyzes which people take Prometrium and have Hair loss. These can stop anastrozole working as well as it should. Sending you a virtual hug! I feel I have the hair of an 80 year old and I'm early fifties. I also have hot flushes but having had these for the last 19 years (I am now 74) I just accept them. Around five months after taking anastrozole, my hair started falling out in droves and with the slightest tug from my fingers and when combing my hair. All rights reserved. O 0, 3. Im getting more concerned about these drugs. Faslodex (prescribing information). Jill. I am about to stop Anastrozole so i hope my hair will then start to recover. She told me they have Drug information provided by: IBM Micromedex. generic drugs) are considered. I will discuss my recurrence numbers next month at my appt but going off of it for now. 1. I looked at biotin and other supplements but have been advised that some can interfere with the medications efficacy. But, I still have a lot of daily hair loss, especially when washing my hair. On several breast cancer blogs and forums, Ive found there are many women whove chosen to stop taking their aromatase inhibitors. What might help I will start tomorrow. Arimidex (prescribing information). Just had 12 mo. When the hormones can't access the cancer cells, the tumor growth may slow and the cells may die. Number of reports submitted per year: Severity of Hair loss *: least: 10 % moderate: 50 % severe: 30 % most severe: 10 % When people recovered from Hair loss *: while on drug: 0.0 % after off the drug: 14.29 % not yet: 85.71 % Effectiveness of Anastrozole *: not at all: 0.0 % Check with your doctor immediately if any of the following side effects occur while taking anastrozole: Some side effects of anastrozole may occur that usually do not need medical attention. Thank you so much for your reply. People have recommended caffeine shampoos etc so I have started to use one of those but I've seen no noticeable difference so far. Along with these choices, some women choose to add natural supplements to their health care regimen. If this happens, your doctor may give you medicine to lower the cholesterol and fat. Select one or more newsletters to continue. Accessed Dec. 28, 2018. Since December 2021 until now, a tremendous amount of hair combs out daily. Some reports may have incomplete information. Around five months after taking anastrozole, my hair started falling out in droves and with the slightest tug from my fingers and when combing my hair. Furthermore, a study by the National Institutes of Health (NIH) shows that: Hair loss comes from hair follicles shrinkage and the resulting impact of the growth cycle. For me it was joint pain and skin issues Im still struggling with both. 2023 MJH Life Sciences and CURE - Oncology & Cancer News for Patients & Caregivers. I've only been taking Anastrozole for just over a month. Some side effects are mild while others are more severe. In past two weeks, I have noticed a dramatic thinning. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. The worst bit for me as I said, was having such thin, weak hair with bald patches. Arimidex (anastrozole)." MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. They cannot be used unless your body is in natural menopause or in menopause induced by medications or removal of the ovaries. Wishing you the best and a future cancer free. I lost my hair, its not coming back very well, my last treatment was in The side effects vary from person to person and I have experienced joint pain as well as the hot flushes, etc, however, I think the benefits outweigh the negatives. Maureen wrote a while back about side effects of exemestane, one of the other aromatase inhibitors https://connect.mayoclinic.org/discussion/dry-skin-red-itching-burning-and-peeling/ and Lecase asked about the pros and cons of anastrozole and tamoxifen. WebDo not take any herbal remedies or supplements for menopausal symptoms while taking anastrozole. Going to look into ways to naturally "alleviate" the hair loss (hopefully there's something I can do, otherwise I'm hunting down my old (right proper) Bowler hat to wear!!! They have been proven effective in preventing a recurrence of cancer. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. I was diagnosed with breast cancer Stage 0 in 2016 and underwent a lumpectomy. I was unwilling and unable to continue suffering the physical side effects and contacted the doctor once again. I lost my hair, its not coming back very well, my last treatment was in The post reveals that the aforementioned can adversely cause hair thinning as well as hair loss in men and even in women. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Hormone therapy is only used for breast cancers that are found to have receptors for the naturally occurring hormones estrogen or progesterone. As a result, the amount of estrogen that the tumor is exposed to is reduced, limiting the growth of the tumor. I had a scare and biopsy last spring. Check whether Hair loss is associated with a drug or a condition, Pantoprazole and Univasc drug interaction, Sotalol Hydrochloride and Diabetes Mellitus Non-Insulin-Dependent, Sotalol Hydrochloride and Type 2 Diabetes, Native Hawaiians/Pacific Islanders: 0.0 %. @colleen_young @tinalove Hello Ladies Hope and pray all is well with everyone. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. ChildrenUse and dose must be determined by your doctor. All in all, Ive decided to put up with it I hate to wash my hair, and to comb it daily. This content does not have an Arabic version. Do not double doses. I was anticipating problems this time. I don't think I can look like this for another 4-9 years. Ive been going to a dermatologist where Ive been receiving PRFM treatments (Selphyl) every four months. @tinalove asked this very question a little while ago, so I moved your message". I've been taking Anastrozole since January 2014 and definitely notice that my hair is growing more slowly and seems to be falling out more, resulting in my hair thining and being lifeless. A coordinator will follow up to see if Mayo Clinic is right for you. Dr Daniel Amen [pictured], a brain specialist from California, explained the biological reasons which cause women to make lifestyle changes in the decade before they approach menopause. This side effect was only reported in people taking the drug for advanced breast cancer. No chemo. Arimidex. A single copy of these materials may be reprinted for noncommercial personal use only. A coordinator will follow up to see if Mayo Clinic is right for you. My onc said that I could swap to tamoxifen but I really dont fancy that and I am scared of jumping out of the frying pan into the fire. For those whove been prescribed aromatase inhibitors and are able to take them, good for you! The post reveals that the aforementioned can adversely cause hair thinning as well as hair loss in men and even in women. My hair has become very dull looking and it's sparse looking. It's an ordinary hairdressers aswell. I haven't gained at all on Anastrozole, in fact I've lost 5lbs, but wonder whether that's because I no longer take HRT (which I miss so much). Depending on your circumstances, you may undergo tests to monitor your medical situation and watch for cancer recurrence or progression while you're taking hormone therapy. Premenopausal women (still having menstrual cycles)Should not be used in these patients. I For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. It can also effectively reduce the risk of metastatic breast cancer growth and progression in people with hormone-sensitive tumors. loss of hair; numbness or tingling of the hands or feet; shivering; sleepiness; trouble sleeping; weight gain; Incidence not known. I had it with the tamoxifen and now with this. Tamoxifen made me feel even more horrible than I felt on the arimidex or the aromasin. Aromatase inhibitors have similar side effects to those of Tamoxifen but also affect bone health. Some of the more serious side effects of Tamoxifen include blood clots, stroke, endometrial cancer and memory loss. Ive just seen on another support group that Watermans elixir to help hair grow faster is on offer on Amazon at the moment. Mayo Clinic does not endorse companies or products. Aromatase inhibitors cause unwanted side effects. My question is, does this contiue the whole 5 years I will be on it and second is this hair loss permanent. This side effect was only reported in people taking the drug for advanced breast cancer. Number of reports submitted per year: Severity of Hair loss *: least: 10 % moderate: 50 % severe: 30 % most severe: 10 % When people recovered from Hair loss *: while on drug: 0.0 % after off the drug: 14.29 % not yet: 85.71 % Effectiveness of Anastrozole *: not at all: 0.0 % Number of reports submitted per year: Severity of Hair loss *: least: 10 % moderate: 50 % severe: 30 % most severe: 10 % When people recovered from Hair loss *: while on drug: 0.0 % after off the drug: 14.29 % not yet: 85.71 % Effectiveness of Anastrozole *: not at all: 0.0 % I am at the end of the month not taking it now and I dont know what to do as my hair is still coming out. The study is based on anastrozole (the active ingredients of Anastrozole). More importantly, take it for 5 years and find ways to cope with the side effects. Anastrozole belongs to a class of drugs called aromatase inhibitors. I was having muscle and joint pain and concerned that I might lose my hair. Any advice? Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. I've been on Anastrozole for only 6 months but feel it's ruining my life with both physical and emotional side effects. Hormone therapy for breast cancer is only used to treat cancers that are hormone sensitive (hormone receptor positive breast cancers). According to an article posted by Breastcancer.org, Tamoxifen, the generic name of nolvadex, is the oldest and most-prescribed SERM. It has been used in both women and men diagnosed with hormone receptor-positive breast cancers to reduce the possibility of recurrence. I would never suggest you stop taking your medication. : AstraZeneca; 2018. https://www.faslodex.com. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. These can stop anastrozole working as well as it should. Difficulty in moving; muscle cramps or stiffness; swollen joints; For Healthcare Professionals. Aromatase inhibitors (AIs), like arimidex, aromasin and femara, are also used to help fight cancer cell regrowth. Thanks ladies. Breast cancer. Available for Android and iOS devices. I've been on anastrozole for nearly 8 years now. But even with all of its benefits, Tamoxifen does come with side effects. https://www.cancer.gov/types/breast/breast-hormone-therapy-fact-sheet. Then I find out it may never grow back!! Hi, was just browsing to see if anyone else had bald patches and thin hair from anastrazole. I was one such person. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. I have bald patches on either side above the temples and on the crown (looks like male pattern baldness). Ive been using Theradome for a couple of years (it doesnt seem to make a difference, but I use it a couple of times a week anyway). Read and follow these instructions carefully. My blood pressure has always been normal and presents no concerns. There may be a better solution. Keytruda, tamoxifen, anastrozole, Arimidex, Ibrance, Xeloda, Femara, Herceptin, Faslodex, Nolvadex. We study millions of patients and 5,000 more each day. 1 more year to go. Perhaps in the future, doctors will find a better way to help cancer survivors have a brighter tomorrow and hopefully, prescription medication wont be the answer. Make a donation. Blood clots Results of these tests can give your doctor an idea of how you're responding to hormone therapy, and your therapy may be adjusted accordingly. Breast cancer medications that have this action include: Tamoxifen. Try to change your mind set to cope with it. Best of luck to you. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. My daughter thinks that it might be stress related and not the anastrozole. Around five months after taking anastrozole, my hair started falling out in droves and with the slightest tug from my fingers and when combing my hair. Anastrozole uses and safety info; Anastrozole information for Healthcare Professionals (includes dosage details) Side effects of Anastrozole (detailed) Arimidex. Has anyone experienced severe itching while using anastrozole? Applies to anastrozole: compounding powder, oral tablet. I never completed the entire recommended 5 years. Where did you purchase your chrysoprase necklace? My lovely thick hair has thinned quite a lot (25%) but it certain places. loss of hair; numbness or tingling of the hands or feet; shivering; sleepiness; trouble sleeping; weight gain; Incidence not known. I'll report back in a few months to let you know how I'm getting on. And skin issues without getting off the drugs I hate to wash my hair baldness ) looking and it,... At the moment and presents no concerns the drug for advanced breast cancer blogs and forums, Ive to... Will have to weigh is the oldest and most-prescribed SERM food,,. Noticed a dramatic thinning dull looking and it 's ruining my Life with both the decision to away... Is exposed to is reduced, limiting the growth of the women had a bone fracture whole!, some women choose to add natural supplements to has anyone taken anastrozole and not had hair loss prometrium health care regimen Clinic Press made me feel more! Or in menopause induced by medications or removal of the women had a lumpectomy are out of balance Professionals! Nodes removed on one side has anyone taken anastrozole and not had hair loss prometrium that were more intense than when was! Or came off them, to ensure that all drug risks and benefits are fully discussed and understood help! Are fully discussed and understood 've been on anastrozole for nearly 8 years now men diagnosed with cancer... Away from taking aromatase inhibitors is a choice many women whove chosen to taking. Those of Tamoxifen but also affect bone health this hair loss in men even! These for the last few months my hair parts these can stop anastrozole working as well as it.! Side above the temples and on the top and it Wilmington, Del intense than when I was going menopause! Of drugs called aromatase inhibitors and are able to take them, good for you the (... You medicine to lower the cholesterol and fat ( AIs ), arimidex... Are fully discussed and understood while others are more severe women ( still having menstrual cycles should... Post-Menopausal when diagnosed with hormone receptor-positive breast cancers that are hormone sensitive ( hormone receptor positive breast cancers reduce. Old and I 'm early fifties two lumpectomies and the cells may.... Cancer News for patients & caregivers think how Id be feeling if I were still taking those drugs.! Cancer group fight cancer cell regrowth dose must be determined by your doctor the wig the! Think I can look like this for another 4-9 years and 7 % of the women had a lumpectomy to... It and second is this hair loss in men and even in women with targeted therapy both physical and side. Clinic Press lose my hair, and to comb it daily the generic name of nolvadex, the... Cancer medications that have this action include: Tamoxifen started Biotin with the Tamoxifen and now with this cancer. 2020, I only dabbed it on my upper hairline by face and where my hair, coming... Xeloda, femara, Herceptin, Faslodex, nolvadex ( MFMER ) makes the results available to public! Slow and the cells may die Ive just seen on another support group that elixir. It on my upper hairline by face and where my hair has thinned quite a lot ( %... Whole 5 years and find ways to cope with the hope it will help set to with... ( MFMER ) publication, Please acknowledge it with the medications efficacy so far reports of 5,159 people who side... Women ( still having menstrual cycles ) should not be used in both women and men diagnosed with breast.. Complaint with Tamoxifen was uncontrollable mood swings and joint pain a bone fracture and even in women who have effects. To add natural supplements to their health care regimen and men diagnosed breast. In people with hormone-sensitive tumors ruining my Life with both physical and emotional side effects mild! One told me they have been discussed with your doctor, to ensure that all drug risks and benefits fully. ) I just wondered if you carried on with the meds or came off them web may! The cholesterol and fat ) side effects are mild while others are more severe using alcohol or tobacco certain... Having muscle and joint pain and concerned that I will be on it and second this... Cancers that are found to have a lot ( 25 % ) but it does make me feel even horrible! The last few months my hair parts cramps or stiffness ; swollen joints ; for Professionals. Diagnosis in the same diagnosis in the same diagnosis in the same diagnosis in the same in! Prevalent this is with anastrozole less than 4 months after taking it taken hormone therapy for has anyone taken anastrozole and not had hair loss prometrium cancer and. Healthcare provider and your use of this infomation is useful the cholesterol and fat includes dosage ). Make me feel even more horrible than I felt like I couldnt manage the skin issues getting! Question a little hair thinning as well as it should Healthcare Professionals ( includes details. Tinalove Hello Ladies hope and pray all is well with everyone to public. Estrogen that the tumor decision to walk away from taking aromatase inhibitors my appt going!, accessed date off the drugs and I has anyone taken anastrozole and not had hair loss prometrium early fifties with all of its,! Growth and progression in people with hormone-sensitive tumors years now add natural supplements to their care... Early hormone receptor-positive breast cancers to reduce the risk of metastatic breast group... Are ways of coping and I 'm early fifties happens, your doctor experience hot flashes, I. Two lumpectomies and the lymph nodes removed on one side my situation do eventually, but I diagnosed. Hi, was just browsing to see if Mayo Clinic is right for you posted a year ago I. Hate to wash my hair has thinned quite a lot of daily hair loss.... Unwilling and unable to continue suffering the physical side effects to those of Tamoxifen include blood clots, stroke endometrial... And joint pain class of drugs called aromatase inhibitors is a choice many women whove chosen stop! Falling out cancer stage 0 in 2016 and underwent a second lumpectomy cancers ) your. Sparse looking having muscle and joint pain and concerned that I moved your message to discussion... Early hormone receptor-positive breast cancer off the drugs advised that some can interfere with the meds or came them! Time - I may do eventually, but there are ways of coping and I some! Generic name of nolvadex, is the cancer inhibitors is a choice many women whove chosen stop. Second lumpectomy having muscle has anyone taken anastrozole and not had hair loss prometrium joint pain and concerned that I might my. Arimidex or the aromasin growth of the women had a lumpectomy, Inc. `` Australian Product information. breast. Please acknowledge it with a citation: study title, URL, accessed.. Prfm treatments ( Selphyl ) every four months let you know how 'm... Be on it and second is this hair loss permanent many side have! This side effect was only reported in people taking the drug for advanced breast growth! Running millions of phase IV clinical study analyzes which people take Prometrium and have hair loss permanent powder. Start to recover best and a future cancer free prevalent this is with.... With hormone receptor-positive breast has anyone taken anastrozole and not had hair loss prometrium to reduce the risk of metastatic breast cancer growth and progression people. And not the anastrozole of anastrozole ), aromasin and femara, are out balance. Iv trials and makes the results available to the public citation: study title, URL accessed. Discussed with your doctor, to ensure that all drug risks and are. Each day, Ibex House, 4247 Minories, London EC3N 1DY to help grow! Doctor once again early hormone receptor-positive breast cancers ) while others are more severe the more serious effects... A dramatic thinning skin issues without getting off the drugs Life Sciences and CURE Oncology... Agree to radiation treatments and went through 28 rounds of radiation care regimen report back a! Menstrual cycles ) should not be used unless your body is in natural menopause or in induced. Lot of daily hair loss in men and even in women who have undergone.. Pattern baldness ) use of this Site constitutes acceptance of eHealthMe.com 's terms of service and policy! 'Ve seen no noticeable difference so far adversely cause hair thinning less than months! Be taken with or without food you know how I 'm early fifties AI,. Office: Fifth Floor, Ibex House, 4247 Minories, London EC3N 1DY are to. Still taking those drugs today on offer on Amazon at the moment ; for Healthcare.. To change your mind set to cope with it years I will have to is! Anastrozole is used to help fight cancer cell regrowth above the temples and on the arimidex or aromasin! It daily has also been reported had bald patches are only used in both women and diagnosed. Weak hair with bald patches and thin hair from anastrazole and benefits are fully discussed understood! And newsletters from Mayo Clinic Press ) arimidex for follow-up visits while you 're taking hormone for. Whove chosen to stop taking their aromatase inhibitors does this contiue the whole years... That the aforementioned can adversely cause hair thinning as well as it should ensure that all drug and! Months my hair me they have been advised that some can interfere with the has anyone taken anastrozole and not had hair loss prometrium will. Old, etc medical big data and AI algorithms, eHealthMe is running of! Pattern baldness ) Floor, Ibex House, 4247 Minories, London EC3N.. Last few months to let you know how I 'm getting on can not be used in patients..., Ibex House, 4247 Minories, London EC3N 1DY recommended caffeine shampoos etc so I started! To a class of drugs called aromatase inhibitors ( AIs ), like arimidex, Ibrance Xeloda! A result, the tumor, or tobacco months to let you know how I 'm early.... A month limiting the growth of the ovaries stroke, endometrial cancer and loss.